ADAM Metallopeptidase Domain 17 (ADAM17) antibody

Antigen: ADAM Metallopeptidase Domain 17 (ADAM17)

Synonyms: CSVP, TACE, ADAM18, CD156B, MGC71942, Tace, CD156b, ADAM17, adam17, si:dkey-81b15.2

Host: Goat

Catalog no.: ABIN647517

Additional Information

Characteristics: Goat Anti-ADAM17 / TACE, with HRP-conjugated secondary antibody

Alternative name: ADAM17 / TACE

Swiss-Prot: NP_003174.3

Immunogen: Peptide with sequence LQRQNRVDSKETEC, from the C Terminus of the protein sequence according to NP_003174.3. was used as immunogen.

Cross-Reactivity: Mouse (Murine), Rat (Rattus)

Reconstitution: Supplied as 100 µg of purified antibody. 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Please avoid freeze-thaw cycles.

Isotype: IgG  (Matching secondary antibodies)

Description: ADAM17, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme), CSVP, TACE, cSVP, CD156b, CD156b, MGC71942, TACE, cSVPADAM metallopeptidase domain 17, TNF-alpha converting enzyme, a disintegrin and metalloproteinase domain 17, a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme), snake venom-like protease. Tumor necrosis factor beta (TNFbeta), also known as lymphotoxin, is a pleiotropic cytokine that has a molecular weight of 25 kDa. TNFalpha, also known as cachetin, is a 17 kDa cytokine that binds to the same receptors, producing an array of effects similar to those of TNFbeta. TNFbeta and TNFalpha share 30% amino acid homology and have similar biological activities. TNFbeta is produced by activated lymphocytes, including CD4+ T helper cell type 1 lymphocytes, CD8+ lymphocytes and certain B lymphoblastoid cell lines. TNFalpha is produced by several different cell types, including lymphocytes, neutrophils and macrophages. TNFbeta and TNFalpha can modulate many immune and inflammatory functions while having the ability to inhibit tumor growth. TACE (for TNFalpha converting enzyme) is a metalloproteinase that cleaves the membrane-bound TNFalpha precursor to release soluble TNFalpha.

Specificity: The ADAM17 goat antibody detects protein derived from human recombinant protein and HELA lysate at various concentrations.

Application Details

Storage: Store at -20 ° C, if not intended for use within a month, Keep it at 4 ° C and minimize freezing and thawing when use.

Restrictions: For Research Use only