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SRY (Sex Determining Region Y)-Box 2 (SOX2) (pSer249) antibody

Antigen

SRY (Sex Determining Region Y)-Box 2 (SOX2)
Synonyms ANOP3, MCOPS3, MGC2413, RGD1565646, SOX2, MGC148683, lcc, ysb, Sox-2
Binding Site
Alternatives

pSer249
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Dot Blot (Dot), ELISA
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN650873
Quantity 0.1 mg  (0.25 mg/ml)
Price 280.50 $   Plus shipping costs $45.00
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anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (pSer249) antibody

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name Sox2
Gene ID 6657
UniProt NP_003097.1, P48431
Immunogen This phospho-Sox2-pS249 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between amino acids 230-260 surrounding S249 of human Sox2.
Isotype Ig
Description Other names: SOX2,
Characteristics Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Specificity This phospho-Sox2-pS249 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between amino acids 230-260 surrounding S249 of human Sox2.
Molecular Weight 34310 DA
Comments

Background: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

Application Details
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Application Notes The suggested dilution is: ELISA ~~ 1:1,000 Dot blot 1:500
Concentration 0.25 mg/ml
Purification Purified
Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is first purified by protein A affinity chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with peptides. The antibody is
Storage Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles
Research Area Ubiquitin-related antibodies, Translation Factors, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Restrictions For Research Use only

Publications
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Product Kamachi, Uchikawa, Kondoh: "Pairing SOX off: with partners in the regulation of embryonic development." in: Trends in genetics : TIG, Vol. 16, Issue 4, pp. 182-7, 2000 (PubMed).

Laga, Lai, Zhan et al.: "Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology." in: The American journal of pathology, Vol. 176, Issue 2, pp. 903-13, 2010 (PubMed).

Alternatives
Application Details Publications Images back to top

Alternatives for antigen "SRY (Sex Determining Region Y)-Box 2 (SOX2)", type "Antibodies"
Hosts Rabbit (94), Mouse (22), Goat (4)
Reactivities Human (115), Mouse (Murine) (41), Rat (Rattus) (32), Dog (Canine) (23), Pig (Porcine) (23), Chicken (22), Cow (Bovine) (22), Sheep (Ovine) (20), Guinea Pig (18), Xenopus laevis (2), Zebrafish (2), Zebrafish (Danio rerio) (2), Cat (Feline) (1), Chimpanzee (1), Monkey (1), Opossum (Didelphimorphia) (1), Rhesus Monkey (1), Salmon (Salmonidae) (1)
Applications Western Blotting (WB) (84), ELISA (63), Immunofluorescence (IF) (34), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (22), Immunohistochemistry (IHC) (16), Immunocytochemistry (ICC) (11), Flow Cytometry (FACS) (6), Dot Blot (Dot) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Dot Blot (DB) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes C-Term (22), N-Term (18), AA 1-170 (3), AA 100-150 (2), AA 50-100 (2), AA 76-80 (2), Ala30 (2), Center (2), Cys265 (2), Internal Region (2), pSer246 (2), C-Term, AA 240-260 (1), pSer250 (1), pSer251 (1), pSer83 (1), pTyr108 (1)