SRY (Sex Determining Region Y)-Box 2 (SOX2) (pSer249) antibody

Details for Product No. ABIN650873
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Antigen
Synonyms Qscn6, Qsox, Sox-2, rSOx, ANOP3, MCOPS3, RGD1565646, SRY-box2, Xsox-2, anop3, mcops3, sox-2, lcc, ysb, cb236, wu:fb83g04, wu:fc14d07, zgc:65860, zgc:77389
Epitope
pSer249
(42), (9), (9), (7), (7), (6), (6), (4), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(196), (66), (45), (21), (20), (20), (16), (12), (5), (4), (4), (3), (2), (2), (1), (1), (1)
Host
Rabbit
(159), (43), (5)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(11), (6), (6), (6), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Dot Blot (DB)
(145), (74), (39), (34), (31), (29), (25), (24), (10), (10), (8), (3), (1)
Pubmed 2 references available
Quantity 400 µL
Options
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Catalog No. ABIN650873
291.50 $
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Immunogen This Sox2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S249 of human Sox2.
Clone RB27265
Isotype Ig
Specificity This phospho-Sox2-pS249 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between amino acids 230-260 surrounding S249 of human Sox2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Sox2
Background This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Synonyms: SOX2,
Molecular Weight 34310 DA
Gene ID 6657
NCBI Accession NP_003097
UniProt P48431
Research Area Ubiquitin-related antibodies, Translation Factors, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes DB = 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (pSer249) antibody Dot blot analysis of anti-phospho-Sox2-pS249 Phospho-specific Pab(ABIN650873) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL.
Background publications Kamachi, Uchikawa, Kondoh: "Pairing SOX off: with partners in the regulation of embryonic development." in: Trends in genetics : TIG, Vol. 16, Issue 4, pp. 182-7, 2000 (PubMed).

Laga, Lai, Zhan et al.: "Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology." in: The American journal of pathology, Vol. 176, Issue 2, pp. 903-13, 2010 (PubMed).

Validation Images
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