B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A) (C-Term) antibody

Antigen: B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A)

Synonyms: Evi9, Ctip1, BCL-11A, mKIAA1809, 2810047E18Rik, D930021L15Rik, EVI9, CTIP1, ZNF856, HBFQTL5, BCL11A-L, BCL11A-S, FLJ10173, FLJ34997, KIAA1809, BCL11A-XL, MGC136898, wu:fi09f10, zgc:136898

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN653582

Additional Information

Alternative name: BCL11A

Gene ID: 53335

UniProt: Q9H165

Immunogen: This BCL11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 806~835 amino acids from the C-terminal region of human BCL11A.

Isotype: Ig

Description: Other names: Ecotropic viral integration site 9 protein homolog, EVI-9, COUP-TF-interacting protein 1, B-cell CLL/lymphoma 11A, B-cell lymphoma/leukemia 11A, BCL-11A, KIAA1809, EVI9, CTIP1, BCL11A

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This BCL11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 806~835 amino acids from the C-terminal region of human BCL11A.

Molecular Weight: 91197 DA

Comments:

Background: BCL11A is a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Transcription Factors, Signaling

Restrictions: For Research Use only

Images

Western blot analysis of BCL11A Antibody (C-term) (ABIN653582) in Jurkat, Ramos, 293, NCI-H460 cell line lysates (35ug/lane). BCL11A (arrow) was detected using the purified Pab.

Publications

Product: Solovieff, Milton, Hartley et al.: "Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster." in: Blood, Vol. 115, Issue 9, pp. 1815-22, 2010 (PubMed).

Nuinoon, Makarasara, Mushiroda et al.: "A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E." in: Human genetics, Vol. 127, Issue 3, pp. 303-14, 2010 (PubMed).