ADH4 antibody (C-Term)

Catalog No. ABIN654087

This anti-ADH4 antibody is a Rabbit Polyclonal antibody detecting ADH4 in WB, FACS and IHC (p). Suitable for Human and Mouse. This Primary Antibody has been cited in 2+ publications.

Quick Overview for ADH4 antibody (C-Term) (ABIN654087)

Target: ADH4 (Alcohol Dehydrogenase 4 (Class II), pi Polypeptide (ADH4))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADH4 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB21606

Product Details anti-ADH4 Antibody

Binding Specificity: AA 319-348, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ADH4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 319-348 amino acids from the C-terminal region of human ADH4.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-ADH4 antibody (ABIN654087)

Attignon, Leblanc, Le-Grand, Duval, Aggerbeck, Rouach, Blanc: "Novel roles for AhR and ARNT in the regulation of alcohol dehydrogenases in human hepatic cells." in: Archives of toxicology, Vol. 91, Issue 1, pp. 313-324, (2017) (PubMed).

Renon, Legrand, Blanc, Daubigney, Bokobza, Mortreux, Paul, Delabar, Rouach, Andreau, Janel: "Impact of Dyrk1A level on alcohol metabolism." in: Biochimica et biophysica acta, Vol. 1862, Issue 9, pp. 1495-503, (2016) (PubMed).

Target Details for ADH4

Target: ADH4 (Alcohol Dehydrogenase 4 (Class II), pi Polypeptide (ADH4))

Alternative Name: ADH4

Background: This gene encodes class II alcohol dehydrogenase 4 pi subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class II alcohol dehydrogenase is a homodimer composed of 2 pi subunits. It exhibits a high activity for oxidation of long-chain aliphatic alcohols and aromatic alcohols and is less sensitive to pyrazole. This gene is localized to chromosome 4 in the cluster of alcohol dehydrogenase genes.

Molecular Weight: 40222

Gene ID: 127

NCBI Accession: NP_000661

UniProt: P08319

Pathways: Transition Metal Ion Homeostasis