Transcription Factor A, Mitochondrial (TFAM) (C-Term) antibody

Antigen: Transcription Factor A, Mitochondrial (TFAM)

Synonyms: TCF6, MtTF1, mtTFA, TCF6L1, TCF6L2, TCF6L3, Hmgts, tsHMG, AI661103, Mttfa, tcf6, mttf1, mttfa, tcf6l1, tcf6l2, tcf6l3, mttfa-A, xl-mtTFA, TFAM, MGC153358, zgc:153358

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN654229

Additional Information

Alternative name: TFAM

Gene ID: 7019

UniProt: Q00059, NP_003192.1

Immunogen: This TFAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-254 amino acids from the C-terminal region of human TFAM.

Isotype: Ig

Description: Other names: Transcription factor A, mitochondrial,TFAM,TCF6, TCF6L2

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This TFAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-254 amino acids from the C-terminal region of human TFAM.

Molecular Weight: 29097 DA

Comments:

Background: This gene encodes a mitochondrial transcription factor that is a key activator of mitochondrial transcription as well as a participant in mitochondrial genome replication. Studies in mice have demonstrated that this gene product is required to regulate the mitochondrial genome copy number and is essential for embryonic development. A mouse model for Kearns-Sayre syndrome was produced when expression of this gene was eliminated by targeted disruption in heart and muscle cells.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Translation Factors, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Publications

Product: Shulman, Chibnik, Aubin et al.: "Intermediate phenotypes identify divergent pathways to Alzheimer's disease." in: PLoS ONE, Vol. 5, Issue 6, pp. e11244, 2010 (PubMed).