|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Inositol Polyphosphate-5-Phosphatase, 75kDa (INPP5B) (C-Term) antibody
|Synonyms||5PTase, MGC65156, MGC71303|
Alternatives Western Blotting (WB), ELISA
|4 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This INPP5B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 957-987 amino acids from the C-terminal region of human INPP5B.|
|Description||Other names: INPP5B,Type II inositol-1,4,5-trisphosphate 5-phosphatase,|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This INPP5B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 957-987 amino acids from the C-terminal region of human INPP5B.|
|Molecular Weight||112852 DA|
Background: Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). INPP5B encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq].
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Metabolism, Cell Structure|
|Restrictions||For Research Use only|
Jänne, Rochelle, Martin-DeLeon et al.: "Mapping of the 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b) to distal mouse chromosome 4 and its exclusion as a candidate gene for dysgenetic lens." in: Genomics, Vol. 28, Issue 2, pp. 280-5, 1996 (PubMed).
Williams, Choudhury, McKenzie et al.: "Targeting of the type II inositol polyphosphate 5-phosphatase INPP5B to the early secretory pathway." in: Journal of cell science, Vol. 120, Issue Pt 22, pp. 3941-51, 2007 (PubMed).
Mao, Balkin, Zoncu et al.: "A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism." in: The EMBO journal, Vol. 28, Issue 13, pp. 1831-42, 2009 (PubMed).
Coon, Mukherjee, Hanna et al.: "Lowe syndrome patient fibroblasts display Ocrl1-specific cell migration defects that cannot be rescued by the homologous Inpp5b phosphatase." in: Human molecular genetics, Vol. 18, Issue 23, pp. 4478-91, 2009 (PubMed).
|Reactivities||Human (6), Mouse (Murine) (4), Rat (Rattus) (4), Cat (Feline) (1), Chicken (1), Cow (Bovine) (1), Dog (Canine) (1)|
|Applications||Western Blotting (WB) (7), ELISA (6), Immunohistochemistry (IHC) (4), Immunofluorescence (IF) (1), Immunoprecipitation (IP) (1)|
|Epitopes||Internal Region (1)|