Achaete-Scute Complex Homolog 2 (Drosophila) (ASCL2) (N-Term) antibody

Antigen: Achaete-Scute Complex Homolog 2 (Drosophila) (ASCL2)

Synonyms: Mash2, bHLHa45, 2410083I15Rik, ASCL2, mash2, ascl2, MASH2

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN654929

Additional Information

Alternative name: ASCL2

Gene ID: 430

UniProt: NP_005161.1, Q99929

Immunogen: This ASCL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the N-terminal region of human ASCL2.

Isotype: Ig

Description: Other names: Achaete-scute homolog 2,ASCL2,BHLHA45, HASH2

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This ASCL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the N-terminal region of human ASCL2.

Molecular Weight: 20185 DA

Comments:

Background: This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Cycle, Transcription Factors, Signaling, Neurology, Cell Structure

Restrictions: For Research Use only

Images

ASCL2 Antibody (N-term) (ABIN654929) western blot analysis in mouse bladder tissue lysates (35ug/lane). This demonstrates the ASCL2 antibody detected the ASCL2 protein (arrow).

Publications

Product: Barrett, Clayton, Concannon et al.: "Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes." in: Nature genetics, Vol. 41, Issue 6, pp. 703-7, 2010 (PubMed).