Engulfment and Cell Motility 2 (ELMO2) (Center) antibody

Antigen: Engulfment and Cell Motility 2 (ELMO2)

Synonyms: CED12, CED-12, ELMO-1, KIAA0281, MGC126406, ELMO-2, FLJ11656, KIAA1834, elmo2, MGC89478, ELMO2, MGC109347, MGC137761, MGC114811, DKFZp469C2416

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN655058

Additional Information

Alternative name: ELMO2

Gene ID: 63916

UniProt: Q96JJ3, NP_877496.1, NP_573403.1

Immunogen: This ELMO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-357 amino acids from the Central region of human ELMO2.

Isotype: Ig

Description: Other names: Engulfment and cell motility protein 2,ELMO2,CED12A, KIAA1834

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This ELMO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-357 amino acids from the Central region of human ELMO2.

Molecular Weight: 82615 DA

Comments:

Background: The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants encoding the same protein.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Images

ELMO2 Antibody (Center) (ABIN655058) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ELMO2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Publications

Product: Rikova, Guo, Zeng et al.: "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." in: Cell, Vol. 131, Issue 6, pp. 1190-203, 2007 (PubMed).