Cleavage and Polyadenylation Specific Factor 3-Like (CPSF3L) (N-Term) antibody

Antigen: Cleavage and Polyadenylation Specific Factor 3-Like (CPSF3L)

Synonyms: RC68, INT11, RC-68, INTS11, CPSF73L, FLJ13294, FLJ20542, AU044035, 2410006F12Rik, MGC124975, RGD1306841, CPSF3L, MGC110671, zgc:110671, DKFZp469C1432, int11

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN655113

Additional Information

Alternative name: CPSF3L

Gene ID: 54973

UniProt: Q5TA45, NP_060341.2

Immunogen: This CPSF3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the N-terminal region of human CPSF3L.

Isotype: Ig

Description: Other names: Integrator complex subunit 11,CPSF3L,INTS11, RC68

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This CPSF3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the N-terminal region of human CPSF3L.

Molecular Weight: 67663 DA

Comments:

Background: The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A, MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1, MIM 180680) and U2 (RNU2, MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Metabolism, Cell Structure

Restrictions: For Research Use only

Publications

Product: Baillat, Hakimi, Näär et al.: "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II." in: Cell, Vol. 123, Issue 2, pp. 265-76, 2005 (PubMed).