Testis Specific Serine Kinase 4 (TSSK4) (C-Term) antibody

Antigen: Testis Specific Serine Kinase 4 (TSSK4)

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN655194

Additional Information

Alternative name: TSSK4

Gene ID: 283629

UniProt: NP_777604.2, Q6SA08

Immunogen: This TSSK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 233-262 amino acids from the C-terminal region of human TSSK4.

Isotype: Ig

Description: Other names: TSSK4,Testis-specific serine/threonine-protein kinase 4,C14orf20, STK22E, TSSK5

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This TSSK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 233-262 amino acids from the C-terminal region of human TSSK4.

Molecular Weight: 37454 DA

Comments:

Background: This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure, Signaling, Protein Modifications, Cell Cycle, Cell Signaling, Chromatin, Phospho-specific antibodies

Restrictions: For Research Use only

Images

TSSK4 Antibody (C-term) (ABIN655194) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TSSK4 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Publications

Product: Chen, Lin, Wei et al.: "TSSK5, a novel member of the testis-specific serine/threonine kinase family, phosphorylates CREB at Ser-133, and stimulates the CRE/CREB responsive pathway." in: Biochemical and biophysical research communications, Vol. 333, Issue 3, pp. 742-9, 2005 (PubMed).

Aston, Krausz, Laface et al.: "Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent." in: Human reproduction (Oxford, England), Vol. 25, Issue 6, pp. 1383-97, 2010 (PubMed).