KLLN antibody (C-Term)

Catalog No. ABIN655558

This Rabbit Polyclonal antibody specifically detects KLLN in WB. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for KLLN antibody (C-Term) (ABIN655558)

Target: KLLN (Killin, p53-Regulated DNA Replication Inhibitor (KLLN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KLLN antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB29503

Product Details anti-KLLN Antibody

Binding Specificity: AA 136-163, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KILLIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-163 amino acids from the C-terminal region of human KILLIN.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-KLLN antibody (ABIN655558)

Wang, Roma, Nolley, Abdul-Karim, Peehl, Eng: "Nuclear KLLN expression associates with improved relapse-free survival for prostate carcinoma." in: Endocrine-related cancer, Vol. 21, Issue 4, pp. 579-86, (2014) (PubMed).

Wang, Yu, He, Romigh, Altemus, Eng: "Activation of AR sensitizes breast carcinomas to NVP-BEZ235's therapeutic effect mediated by PTEN and KLLN upregulation." in: Molecular cancer therapeutics, Vol. 13, Issue 2, pp. 517-27, (2014) (PubMed).

Wang, He, Yu, Eng: "Androgen receptor-induced tumor suppressor, KLLN, inhibits breast cancer growth and transcriptionally activates p53/p73-mediated apoptosis in breast carcinomas." in: Human molecular genetics, Vol. 22, Issue 11, pp. 2263-72, (2013) (PubMed).

Target Details for KLLN

Target: KLLN (Killin, p53-Regulated DNA Replication Inhibitor (KLLN))

Alternative Name: KILLIN

Background: DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating TP53/p53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double-and single-stranded DNA.

Molecular Weight: 19958

Gene ID: 100144748

NCBI Accession: NP_001119521

UniProt: B2CW77