RAP1, GTP-GDP Dissociation Stimulator 1 (RAP1GDS1) (Center) antibody

Antigen: RAP1, GTP-GDP Dissociation Stimulator 1 (RAP1GDS1)

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN655886

Additional Information

Alternative name: RAP1GDS1

Gene ID: 5910

UniProt: NP_001093900.1, P52306

Immunogen: This RAP1GDS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-252 amino acids from the Central region of human RAP1GDS1.

Isotype: Ig

Description: Other names: Rap1 GTPase-GDP dissociation stimulator 1,RAP1GDS1,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This RAP1GDS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-252 amino acids from the Central region of human RAP1GDS1.

Molecular Weight: 66317 DA

Comments:

Background: The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Signaling, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Publications

Product: Tiwari, Felekkis, Moon et al.: "Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis." in: Blood, Vol. 103, Issue 7, pp. 2661-7, 2004 (PubMed).

Branham, Bustos, De Blas et al.: "Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis." in: The Journal of biological chemistry, Vol. 284, Issue 37, pp. 24825-39, 2009 (PubMed).

Schönherr, Yang, Vigny et al.: "Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells." in: Oncogene, Vol. 29, Issue 19, pp. 2817-30, 2010 (PubMed).