Integrator Complex Subunit 1 (INTS1) (N-Term) antibody

Antigen: Integrator Complex Subunit 1 (INTS1)

Synonyms: INT1, FLJ46624, KIAA1440, DKFZp586J0619, 1110015K06Rik, fa14a05, wu:fa14a05, wu:fa55a06, INTS1

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN656190

Additional Information

Alternative name: INTS1

Gene ID: 26173

UniProt: NP_001073922.2, Q8N201

Immunogen: This INTS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human INTS1.

Isotype: Ig

Description: Other names: INTS1,Integrator complex subunit 1,KIAA1440

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This INTS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human INTS1.

Molecular Weight: 244297 DA

Comments:

Background: INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A, MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1, MIM 180680) and U2 (RNU2, MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: INTS1 Antibody (N-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Signaling, Phospho-specific antibodies, Cell Structure, Protein Modifications

Restrictions: For Research Use only

Images

INTS1 Antibody (ABIN656190) western blot analysis in human placenta tissue lysates (35ug/lane). This demonstrates the INTS1 antibody detected the INTS1 protein (arrow).

Publications

Product: Baillat, Hakimi, Näär et al.: "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II." in: Cell, Vol. 123, Issue 2, pp. 265-76, 2005 (PubMed).

Nusbaum, Mikkelsen, Zody et al.: "DNA sequence and analysis of human chromosome 8." in: Nature, Vol. 439, Issue 7074, pp. 331-5, 2006 (PubMed).