delta Like Protein 3 (DLL3) (C-Term) antibody

Antigen: delta Like Protein 3 (DLL3)

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN656327

Additional Information

Alternative name: DLL3

Gene ID: 10683

UniProt: NP_058637.1, Q9NYJ7, NP_982353.1

Immunogen: This DLL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 552-583 amino acids from the C-terminal region of human DLL3.

Isotype: Ig

Description: Other names: DLL3,Delta-like protein 3,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This DLL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 552-583 amino acids from the C-terminal region of human DLL3.

Molecular Weight: 64618 DA

Comments:

Background: This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq].

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: DLL3 Antibody (C-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Ubiquitin-related antibodies, Cell Signaling, Cell Structure, Protein Modifications, Cell Cycle

Restrictions: For Research Use only

Images

DLL3 Antibody (C-term) (ABIN656327) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DLL3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Publications

Product: Bonafé, Giunta, Gassner et al.: "A cluster of autosomal recessive spondylocostal dysostosis caused by three newly identified DLL3 mutations segregating in a small village." in: Clinical genetics, Vol. 64, Issue 1, pp. 28-35, 2003 (PubMed).

Whittock, Ellard, Duncan et al.: "Pseudodominant inheritance of spondylocostal dysostosis type 1 caused by two familial delta-like 3 mutations." in: Clinical genetics, Vol. 66, Issue 1, pp. 67-72, 2004 (PubMed).

Maisenbacher, Han, Obrien et al.: "Molecular analysis of congenital scoliosis: a candidate gene approach." in: Human genetics, Vol. 116, Issue 5, pp. 416-9, 2005 (PubMed).