SHANK2 antibody (AA 879-908)

Catalog No. ABIN656710

This Rabbit Polyclonal antibody specifically detects SHANK2 in WB. It exhibits reactivity toward Mouseand has been mentioned in 1 publication.

Quick Overview for SHANK2 antibody (AA 879-908) (ABIN656710)

Target: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SHANK2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB31120

Product Details anti-SHANK2 Antibody

Binding Specificity: AA 879-908

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SHANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 879-908 amino acids from the Central region of human SHANK2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: SHANK2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

References for anti-SHANK2 antibody (ABIN656710)

de Sena Cortabitarte, Berkel, Cristian, Fischer, Rappold: "A direct regulatory link between microRNA-137 and SHANK2: implications for neuropsychiatric disorders." in: Journal of neurodevelopmental disorders, Vol. 10, Issue 1, pp. 15, (2018) (PubMed).

Target Details for SHANK2

Target: SHANK2 (SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))

Alternative Name: SHANK2

Background: This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined. [provided by RefSeq].

Molecular Weight: 158822

Gene ID: 22941

NCBI Accession: NP_036441

UniProt: Q9UPX8