phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) (C-Term) antibody

Antigen: phosphofurin Acidic Cluster Sorting Protein 2 (PACS2)

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN657066

Additional Information

Alternative name: PACS2

Isotype: Ig

Description: Other names: Phosphofurin acidic cluster sorting protein 2,PACS2,KIAA0602, PACS1L

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This PACS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 641-671 amino acids from the C-terminal region of human PACS2.

Comments:

Background: Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.

Application Details

Concentration: 0.25 mg/ml

Purification: Purified

Research Area: Protein Modifications, Apoptosis/Necrosis, Cell Structure, Phospho-specific antibodies

Restrictions: For Research Use only

Images

PACS2 Antibody (C-term) (ABIN657066) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PACS2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Publications

Product: Atkins, Thomas, Youker et al.: "HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice." in: The Journal of biological chemistry, Vol. 283, Issue 17, pp. 11772-84, 2008 (PubMed).

Myhill, Lynes, Nanji et al.: "The subcellular distribution of calnexin is mediated by PACS-2." in: Molecular biology of the cell, Vol. 19, Issue 7, pp. 2777-88, 2008 (PubMed).