Toll-Like Receptor 7 (TLR7) (C-Term) antibody

Antigen: Toll-Like Receptor 7 (TLR7)

Synonyms: RGD1563357, TLR7A

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN657635

Additional Information

Alternative name: TLR7

Gene ID: 51284

UniProt: NP_057646.1, Q9NYK1

Immunogen: This TLR7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 898-927 amino acids from the C-terminal region of human TLR7.

Isotype: Ig

Description: Other names: Toll-like receptor 7,TLR7,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This TLR7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 898-927 amino acids from the C-terminal region of human TLR7.

Molecular Weight: 120922 DA

Comments:

Background: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on chromosome X.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: TLR7 Antibody (C-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling

Restrictions: For Research Use only

Images

TLR7 Antibody (C-term) (ABIN657635) western blot analysis in HepG2 cell line lysates (35ug/lane). This demonstrates the TLR7 antibody detected the TLR7 protein (arrow).

Publications

Product: Shen, Fu, Deng et al.: "Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 36, pp. 15838-43, 2010 (PubMed).