Chemokine (C-C Motif) Receptor 10 (CCR10) (N-Term) antibody

Antigen: Chemokine (C-C Motif) Receptor 10 (CCR10)

Synonyms: DEZ, ChemR23, CHEMERINR, MGC126105, MGC126106, GPR2, Gpr2, Cmkbr9, MGC151420, Gpcr27, mcmklr1, zgc:91924, CMKLR1, CCR10, si:ch211-240b21.3, Cmklr-1, GPCR

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN657666

Additional Information

Alternative name: CCR10

Gene ID: 2826

UniProt: NP_057686.2, P46092

Immunogen: This CCR10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CCR10.

Isotype: Ig

Description: Other names: C-C chemokine receptor type 10,CCR10,GPR2

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This CCR10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CCR10.

Molecular Weight: 38416 DA

Comments:

Background: Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues, the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27, MIM 604833), CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: CCR10 Antibody (N-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications

Restrictions: For Research Use only

Images

CCR10 Antibody (N-term) (ABIN657666) western blot analysis in HL-60 cell line lysates (35ug/lane). This demonstrates the CCR10 antibody detected the CCR10 protein (arrow).

Publications

Product: Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).