|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (Center) antibody
|Synonyms||CD305, LAIR-1, Lair-1, mLair-1, BB115266, D7Bwg0421e, 5133400O11Rik|
Alternatives Western Blotting (WB), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|UniProt||NP_002278.1, Q6GTX8, NP_068352.1|
|Immunogen||This LAIR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-206 amino acids from the Central region of human LAIR1.|
|Description||Other names: Leukocyte-associated immunoglobulin-like receptor 1,LAIR1,CD305|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This LAIR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-206 amino acids from the Central region of human LAIR1.|
|Molecular Weight||31412 DA|
Background: The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||LAIR1 Antibody (Center) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.|
|Research Area||Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications|
|Restrictions||For Research Use only|
|LAIR1 Antibody (Center) (ABIN657706) western blot analysis in K562 cell line lysates (35ug/lane). This demonstrates the LAIR1 antibody detected the LAIR1 protein (arrow).|
Tang, Narayanan, Peruzzi et al.: "A single residue, arginine 65, is critical for the functional interaction of leukocyte-associated inhibitory receptor-1 with collagens." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 9, pp. 5446-52, 2009 (PubMed).
Brondijk, de Ruiter, Ballering et al.: "Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI." in: Blood, Vol. 115, Issue 7, pp. 1364-73, 2010 (PubMed).
Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).
|Hosts||Mouse (40), Rabbit (20), Hamster (4), Goat (2), Chicken (1)|
|Reactivities||Human (46), Mouse (Murine) (22), Rat (Rattus) (18)|
|Applications||Flow Cytometry (FACS) (41), Western Blotting (WB) (29), Immunoprecipitation (IP) (16), Immunofluorescence (IF) (15), ELISA (13), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6), Functional Studies (Func) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||PE (7), Biotin (5), FITC (5), RPE (2), APC (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), CF (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), HRP (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||AA 22-125 (2), AA 25-122 (1), C-Term (1), Extracellular Domain (1), Internal Region (1)|