Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) (Center) antibody

Antigen: Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1)

Synonyms: CD305, LAIR-1, Lair-1, mLair-1, BB115266, D7Bwg0421e, 5133400O11Rik

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN657706

Additional Information

Alternative name: LAIR1

Gene ID: 3903

UniProt: NP_002278.1, Q6GTX8, NP_068352.1

Immunogen: This LAIR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-206 amino acids from the Central region of human LAIR1.

Isotype: Ig

Description: Other names: Leukocyte-associated immunoglobulin-like receptor 1,LAIR1,CD305

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This LAIR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-206 amino acids from the Central region of human LAIR1.

Molecular Weight: 31412 DA

Comments:

Background: The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: LAIR1 Antibody (Center) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications

Restrictions: For Research Use only

Images

LAIR1 Antibody (Center) (ABIN657706) western blot analysis in K562 cell line lysates (35ug/lane). This demonstrates the LAIR1 antibody detected the LAIR1 protein (arrow).

Publications

Product: Tang, Narayanan, Peruzzi et al.: "A single residue, arginine 65, is critical for the functional interaction of leukocyte-associated inhibitory receptor-1 with collagens." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 9, pp. 5446-52, 2009 (PubMed).

Brondijk, de Ruiter, Ballering et al.: "Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI." in: Blood, Vol. 115, Issue 7, pp. 1364-73, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).