|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Retinoic Acid Receptor, alpha (RARA) (C-Term) antibody
|Synonyms||RAR, NR1B1, Nr1b1, RARalpha1, RARA, rar-alpha|
Alternatives Western Blotting (WB), ELISA
|4 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|UniProt||P10276, NP_001138773.1, NP_000955.1, NP_001019980.1|
|Immunogen||This RARA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321-379 amino acids from the C-terminal region of human RARA.|
|Description||Other names: Retinoic acid receptor alpha,RARA,NR1B1|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This RARA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321-379 amino acids from the C-terminal region of human RARA.|
|Molecular Weight||50771 DA|
Background: This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||RARA Antibody (C-term) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Transcription Factors, Chromatin, Signaling, Cell Structure|
|Restrictions||For Research Use only|
|Confocal immunofluorescent analysis of RARA Antibody (C-term) (ABIN657770) with MCF-7 cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).|
Chen, Guidez, Rousselot et al.: "PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 3, pp. 1178-82, 1994 (PubMed).
Catalano, Dawson, Somana et al.: "The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia." in: Blood, Vol. 110, Issue 12, pp. 4073-6, 2007 (PubMed).
Park, Kim, Um: "A novel cytoplasmic adaptor for retinoic acid receptor (RAR) and thyroid receptor functions as a Derepressor of RAR in the absence of retinoic acid." in: The Journal of biological chemistry, Vol. 285, Issue 44, pp. 34269-78, 2010 (PubMed).
Asleson, Morgan, Smith et al.: "Amplification of the RARA gene in acute myeloid leukemia: significant finding or coincidental observation?" in: Cancer genetics and cytogenetics, Vol. 202, Issue 1, pp. 33-7, 2010 (PubMed).
|Hosts||Rabbit (41), Mouse (9), Goat (5)|
|Reactivities||Human (46), Mouse (Murine) (30), Rat (Rattus) (28), Cow (Bovine) (3), Chicken (1), Dog (Canine) (1), Xenopus laevis (1)|
|Applications||Western Blotting (WB) (36), ELISA (22), Immunofluorescence (IF) (19), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (15), Immunohistochemistry (IHC) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Flow Cytometry (FACS) (2), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1)|
|Conjugates||Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||C-Term (5), N-Term (4), Internal Region (2), AA 1-100 (1), AA 10-25 (1), AA 444-462 (1), pSer77 (1)|