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Details for Product No. ABIN658993

Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody

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Synonyms ALDH-E2, ALDHI, ALDM, Ahd-5, Ahd5, aldh2, aldh2a, zgc:63786, MGC80785, aldh-e2, aldhi, aldm, rf2b
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
Pubmed 5 references available
Catalog no. ABIN658993
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This ALDH2 Monoclonal antibody is generated from mouse immunized with ALDH2 recombinant protein.
Clone 138CT22-3-8
Isotype IgG1, Ig
Specificity This ALDH2 Monoclonal antibody is generated from mouse immunized with ALDH2 recombinant protein.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name ALDH2
Background This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.
Synonyms: ALDH-E2, ALDHI, ALDH class 2, Aldehyde dehydrogenase, mitochondrial,ALDM, ALDH2
Pathways: Glycolysis / Gluconeogenesis, Pyruvate metabolism, Fatty acid metabolism, Glycerolipid metabolism, Histidine metabolism, beta-Alanine metabolism, Arginine and proline metabolism, Valine, leucine and isoleucine degradation, Tryptophan metabolism
Molecular Weight 56381 Da
Gene ID 217
UniProt P05091
Research Area Signaling, Cell Signaling, Stem Cells, Cell Structure
Application Notes Recommend dilutions: WB : 1:100-1000,IHC : 1:50-100,FC : 1:10-50,IF : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Zhou, Diao, Li et al.: "Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia." in: World journal of gastroenterology : WJG, Vol. 16, Issue 27, pp. 3445-9, 2010 (PubMed).

Hendershot, Otto, Collins et al.: "Evaluation of a brief web-based genetic feedback intervention for reducing alcohol-related health risks associated with ALDH2." in: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, Vol. 40, Issue 1, pp. 77-88, 2010 (PubMed).

Weng, Weng, Lu et al.: "Effects of alcohol-drinking behaviour and ADH1B and ALDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay." in: Mutation research, Vol. 701, Issue 2, pp. 132-6, 2010 (PubMed).

Yang, Yokoyama, Yokoyama et al.: "Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis." in: World journal of gastroenterology : WJG, Vol. 16, Issue 33, pp. 4210-20, 2010 (PubMed).

Alternatives for antigen "Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2)", type "Antibodies"
Hosts (40), (16), (3)
Reactivities (58), (29), (27), (13), (1), (1)
Applications (46), (30), (18), (14), (10), (8), (8), (7), (2), (2), (1)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (5), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)