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Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody

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Synonyms aldh2, aldh2a, zgc:63786, MGC80785, aldh-e2, aldhi, aldm, rf2b, ALDH-E2, ALDHI, ALDM, Ahd-5, Ahd5
(140), (26), (24), (4), (3), (2), (1), (1)
(93), (34), (14)
Clonality (Clone)
Monoclonal ()
(8), (7), (6), (6), (6), (6), (1)
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(120), (81), (66), (28), (26), (20), (11), (5), (1), (1), (1)
Pubmed 5 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 10 to 11 Business Days
Immunogen This ALDH2 Monoclonal antibody is generated from mouse immunized with ALDH2 recombinant protein.
Clone 138CT22-3-8
Isotype IgG1, Ig
Specificity This ALDH2 Monoclonal antibody is generated from mouse immunized with ALDH2 recombinant protein.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name ALDH2 (ALDH2 Antibody Abstract)
Background This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.
Synonyms: ALDH-E2, ALDHI, ALDH class 2, Aldehyde dehydrogenase, mitochondrial,ALDM, ALDH2
Pathways: Glycolysis / Gluconeogenesis, Pyruvate metabolism, Fatty acid metabolism, Glycerolipid metabolism, Histidine metabolism, beta-Alanine metabolism, Arginine and proline metabolism, Valine, leucine and isoleucine degradation, Tryptophan metabolism
Molecular Weight 56381 Da
Gene ID 217
UniProt P05091
Research Area Signaling, Cell Signaling, Stem Cells, Cell Structure
Application Notes WB = 1:100-1000, IHC (p) = 1:50-100, FACS = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody (ABIN658993) Western blot analysis of ALDH2 monoclonal antibody in HepG2 cell line lysates (35ug/...
Immunohistochemistry (IHC) image for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody (ABIN658993) ALDH2 Monoclonal Antibody immunohistochemistry analysis in formalin fixed and paraff...
Flow Cytometry (FACS) image for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody (ABIN658993) ALDH2 Monoclonal Antibody flow cytometric analysis of HepG2 cells (right histogram) ...
Immunofluorescence (IF) image for anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody (ABIN658993) Confocal immunofluorescent analysis of ALDH2 Antibody with HepG2 cell followed by Al...
Background publications Yang, Yokoyama, Yokoyama et al.: "Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis." in: World journal of gastroenterology : WJG, Vol. 16, Issue 33, pp. 4210-20, 2010 (PubMed).

Weng, Weng, Lu et al.: "Effects of alcohol-drinking behaviour and ADH1B and ALDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay." in: Mutation research, Vol. 701, Issue 2, pp. 132-6, 2010 (PubMed).

Hendershot, Otto, Collins et al.: "Evaluation of a brief web-based genetic feedback intervention for reducing alcohol-related health risks associated with ALDH2." in: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, Vol. 40, Issue 1, pp. 77-88, 2010 (PubMed).

Zhou, Diao, Li et al.: "Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia." in: World journal of gastroenterology : WJG, Vol. 16, Issue 27, pp. 3445-9, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Catalog No. ABIN658993
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