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Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody

Details for Product No. ABIN658993
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Antigen
Synonyms aldh2, aldh2a, zgc:63786, MGC80785, aldh-e2, aldhi, aldm, rf2b, ALDH-E2, ALDHI, ALDM, Ahd-5, Ahd5
Reactivity
Human
(83), (32), (30), (13), (1), (1)
Host
Mouse
(56), (25), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF)
(71), (47), (38), (20), (17), (16), (14), (10), (2), (2), (1)
Pubmed 5 references available
Quantity 400 µL
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Catalog No. ABIN658993
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Immunogen This ALDH2 Monoclonal antibody is generated from mouse immunized with ALDH2 recombinant protein.
Clone 138CT22-3-8
Isotype IgG1, Ig
Specificity This ALDH2 Monoclonal antibody is generated from mouse immunized with ALDH2 recombinant protein.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name ALDH2
Background This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix.
Synonyms: ALDH-E2, ALDHI, ALDH class 2, Aldehyde dehydrogenase, mitochondrial,ALDM, ALDH2
Pathways: Glycolysis / Gluconeogenesis, Pyruvate metabolism, Fatty acid metabolism, Glycerolipid metabolism, Histidine metabolism, beta-Alanine metabolism, Arginine and proline metabolism, Valine, leucine and isoleucine degradation, Tryptophan metabolism
Molecular Weight 56381 Da
Gene ID 217
UniProt P05091
Research Area Signaling, Cell Signaling, Stem Cells, Cell Structure
Application Notes WB = 1:100-1000, IHC = 1:50-100, FACS = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody Western blot analysis of ALDH2 monoclonal antibody in HepG2 cell line lysates (35ug/lane). ALDH2 (arrow) was detected using the purified mab.(4ug/ml)
anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody (2) ALDH2 Monoclonal Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ALDH2 Monoclonal Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody (3) ALDH2 Monoclonal Antibody flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).PE-conjugated goat-anti-mouse secondary antibodies were used for the analysis.
anti-Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2) antibody (4) Confocal immunofluorescent analysis of ALDH2 Antibody with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue).
Background publications Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Zhou, Diao, Li et al.: "Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia." in: World journal of gastroenterology : WJG, Vol. 16, Issue 27, pp. 3445-9, 2010 (PubMed).

Hendershot, Otto, Collins et al.: "Evaluation of a brief web-based genetic feedback intervention for reducing alcohol-related health risks associated with ALDH2." in: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, Vol. 40, Issue 1, pp. 77-88, 2010 (PubMed).

Weng, Weng, Lu et al.: "Effects of alcohol-drinking behaviour and ADH1B and ALDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay." in: Mutation research, Vol. 701, Issue 2, pp. 132-6, 2010 (PubMed).

Yang, Yokoyama, Yokoyama et al.: "Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis." in: World journal of gastroenterology : WJG, Vol. 16, Issue 33, pp. 4210-20, 2010 (PubMed).

Validation Images
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