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Details for Product No. ABIN659002

Enhancer of Zeste Homolog 2 (Drosophila) (EZH1) antibody

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Antigen
Synonyms eya2, im:7149338, zgc:136376, zgc:152758, Enx-1, Enx1h, KMT6, mKIAA4065, ENX-1, ENX1, EZH1, EZH2b, KMT6A, WVS, WVS2, EZH2, enx-1, enx1, ezh1, kmt6, xez, ezh2, olezh2
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 5 references available
Catalog no. ABIN659002
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This EZH2 antibody is generated from mouse immunized with EZH2 recombinant protein.
Clone 144CT2-1-1-5
Isotype IgG1, Ig kappa
Specificity This EZH2 antibody is generated from mouse immunized with EZH2 recombinant protein.
Predicted Reactivity Monkey
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name EZH2
Background This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Two transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms: Lysine N-methyltransferase 6, ENX-1, Enhancer of zeste homolog 2, Histone-lysine N-methyltransferase EZH2,KMT6, EZH2
Molecular Weight 85363 Da
Gene ID 2146
UniProt Q15910
Research Area Translation Factors
Application Notes Recommend dilutions: IF : 1:10-50,WB : 1:100-500,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Kunderfranco, Mello-Grand, Cangemi et al.: "ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer." in: PLoS ONE, Vol. 5, Issue 5, pp. e10547, 2010 (PubMed).

Wang, Ye, Yuan et al.: "EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis." in: World journal of gastroenterology : WJG, Vol. 16, Issue 19, pp. 2421-7, 2010 (PubMed).

Kikuchi, Kinoshita, Shimizu et al.: "Distinctive expression of the polycomb group proteins Bmi1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance." in: Cancer, Vol. 116, Issue 12, pp. 3015-24, 2010 (PubMed).

Toll, Dasgupta, Potoczek et al.: "Implications of enhancer of zeste homologue 2 expression in pancreatic ductal adenocarcinoma." in: Human pathology, Vol. 41, Issue 9, pp. 1205-9, 2010 (PubMed).

Tsai, Manor, Wan et al.: "Long noncoding RNA as modular scaffold of histone modification complexes." in: Science (New York, N.Y.), Vol. 329, Issue 5992, pp. 689-93, 2010 (PubMed).

Alternatives for antigen "Enhancer of Zeste Homolog 2 (Drosophila) (EZH1)", type "Antibodies"
Hosts (80), (8)
Reactivities (85), (54), (42), (37), (37), (36), (25), (12), (2), (1), (1)
Applications (48), (30), (27), (23), (7), (7), (6), (3), (1), (1), (1), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (12), (12), (12), (4), (2), (2), (2), (1), (1), (1)
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