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Autophagy Related 4D, Cysteine Peptidase (ATG4D) antibody

Details for Product No. ABIN659112, Supplier: Log in to see
Antigen
  • APG4-D
  • APG4D
  • AUTL4
  • 9830134P12Rik
  • Apg4d
  • Atg4dl
  • Autl4
  • apg4d
Reactivity
Human
129
52
38
3
3
1
1
1
1
Host
Mouse
102
15
15
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
7
7
7
5
5
5
4
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
97
51
24
21
18
14
2
Supplier
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Immunogen This ATG4D monoclonal antibody is generated from mouse immunized with ATG4D recombinant protein.
Clone 222CT15-4-1
Isotype IgG1, kappa
Specificity This ATG4D monoclonal antibody is generated from mouse immunized with ATG4D recombinant protein.
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Alternative Name ATG4D (ATG4D Antibody Abstract)
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases.
Synonyms: Cysteine protease ATG4D,ATG4D,APG4D, AUTL4
Pathways: Regulation of autophagy
Molecular Weight 52922 Da
Gene ID 84971
UniProt Q86TL0
Research Area Autophagy, Metabolism, Cell Structure
Pathways
Application Notes IF = 1:25, WB = 1:100-1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Autophagy Related 4D, Cysteine Peptidase (ATG4D) antibody (ABIN659112) ATG4D/MB10250 antibody western blot analysis in HL-60 cell line lysates (35ug/lane)....
Immunofluorescence (IF) image for anti-Autophagy Related 4D, Cysteine Peptidase (ATG4D) antibody (ABIN659112) Confocal immunofluorescent analysis of ATG4D Antibody with Hela cell followed by Ale...
Background publications Betin, Lane: "Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis." in: Journal of cell science, Vol. 122, Issue Pt 14, pp. 2554-66, 2009 (PubMed).

Lamesch, Li, Milstein et al.: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007 (PubMed).

Mariño, Uría, Puente et al.: "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy." in: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 3671-8, 2003 (PubMed).