ATG4 Autophagy Related 4 Homolog C (S. Cerevisiae) (ATG4C) antibody
| Antigen |
|
| Synonyms |
Apg4b, Autl1, Atg4bl, AW048066, 2510009N07Rik, APG4C, AUTL1, AUTL3, APG4-C, FLJ14867, apg4c, atg4cl, zgc:86888, wu:fc56g07, MGC148409 |
| Clonality |
Monoclonal |
|
Host
|
|
|
Reactivity
|
|
|
Conjugate
|
Alexa Fluor 350 (5), Alexa Fluor 488 (5), Alexa Fluor 555 (5), Alexa Fluor 647 (5), Biotin (5), Cy3 (5), Cy5 (5), Cy5.5 (5), Cy7 (5), FITC (5), Gold (5), HRP (5), PE (5), PE,Cy3 (5), PE,Cy5 (5), PE,Cy5.5 (5), PE,Cy7 (5), Alexa Flour 488 (1)
|
|
Application
|
Immunofluorescence (IF) (79), ELISA (44), Western Blotting (WB) (43), Immunohistochemistry (IHC) (17), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (17), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (15), Immunoprecipitation (IP) (6), Dot Blot (DB) (5), Dot Blot (Dot) (5), Immunoelectron Microscopy (IEM) (5), Flow Cytometry (FACS) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1)
|
| Catalog no. |
ABIN659178 |
| Quantity |
0.1 mg (0.25 mg/ml) |
| Price |
280.50 $ Plus shipping costs $45.00
|
|
Bulk discount
|
| Shipping to |
|
| Availability |
Will be delivered in 2 to 3 Business Days |
|
Alternative name
|
ATG4C
|
|
Gene ID
|
84938
|
|
UniProt
|
NP_116241.2, Q96DT6, NP_835739.1
|
|
Immunogen
|
This ATG4C monoclonal antibody is generated from mouse immunized with ATG4C recombinant protein.
|
|
Isotype
|
IgG1 kappa
|
|
Description
|
Other names: ATG4C,Cysteine protease ATG4C,APG4C, AUTL1, AUTL3
|
|
Characteristics
|
Mouse Monoclonal Antibody (Mab)
|
|
Specificity
|
This ATG4C monoclonal antibody is generated from mouse immunized with ATG4C recombinant protein.
|
|
Molecular Weight
|
52497 DA
|
|
Comments
|
Background: Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq].
|
|
Application Notes
|
The suggested dilution is: ELISA~~1:1000 Western blotting~~1:15~120
|
|
Concentration
|
0.25 mg/ml
|
|
Buffer
|
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
|
|
Storage
|
ATG4C Antibody can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.
|
|
Research Area
|
Signaling, Protein Modifications, Autophagy, Metabolism, Cell Structure
|
|
Restrictions
|
For Research Use only
|
|
Product
|
Mariño, Salvador-Montoliu, Fueyo et al.: "Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3." in: The Journal of biological chemistry, Vol. 282, Issue 25, pp. 18573-83, 2007 (PubMed).
Kathiresan, Melander, Guiducci et al.: "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans." in: Nature genetics, Vol. 40, Issue 2, pp. 189-97, 2008 (PubMed).
|
Alternatives for antigen "ATG4 Autophagy Related 4 Homolog C (S. Cerevisiae) (ATG4C)", type "Antibodies"
|
Hosts
|
Rabbit (127), Sheep (3), Mouse (1)
|
|
Reactivities
|
Human (111), Mouse (Murine) (99), Rat (Rattus) (96), Cow (Bovine) (74), Dog (Canine) (74), Pig (Porcine) (73), Horse (Equine) (37), Cat (Feline) (1), Chicken (1)
|
|
Applications
|
Immunofluorescence (IF) (79), ELISA (44), Western Blotting (WB) (43), Immunohistochemistry (IHC) (17), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (17), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (15), Immunoprecipitation (IP) (6), Dot Blot (DB) (5), Dot Blot (Dot) (5), Immunoelectron Microscopy (IEM) (5), Flow Cytometry (FACS) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1)
|
|
Conjugates
|
Alexa Fluor 350 (5), Alexa Fluor 488 (5), Alexa Fluor 555 (5), Alexa Fluor 647 (5), Biotin (5), Cy3 (5), Cy5 (5), Cy5.5 (5), Cy7 (5), FITC (5), Gold (5), HRP (5), PE (5), PE,Cy3 (5), PE,Cy5 (5), PE,Cy5.5 (5), PE,Cy7 (5), Alexa Flour 488 (1)
|
|
Epitopes
|
pSer177 (20), pSer166 (19), pSer398 (19), pSer451 (19), AA 151-181 (2), AA 383-413 (2), C-Term (2), N-Term (2), AA 162-192 (1), AA 174-198 (1), AA 174-204 (1), AA 429-458 (1), C-Term,AA 426-456 (1), Center (1), Internal Region (1), N-Term,AA 40-70 (1)
|
Alternatives 
