S100 Calcium Binding Protein B (S100B) antibody

Details for Product No. ABIN659188
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Antigen
Synonyms AI266795, S100, S100a, NEF, S100-B, S100beta, S100P, AI850290, Bpb
Reactivity
Mouse (Murine)
(130), (44), (42), (37), (13), (9), (4), (4)
Host
Mouse
(97), (58), (4), (4), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(8), (7), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(116), (74), (53), (47), (17), (15), (15), (15), (10), (10), (8), (5), (3), (2), (1), (1)
Pubmed 4 references available
Quantity 400 μL
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Catalog No. ABIN659188
291.50 $
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Immunogen This S100B monoclonal antibody is generated from mouse immunized with S100B recombinant protein.
Clone 271CT14-3-3
Isotype IgM, kappa
Specificity This S100B monoclonal antibody is generated from mouse immunized with S100B recombinant protein.
Predicted Reactivity Rabbit
Purification This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
Alternative Name S100B
Background The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21, however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
Synonyms: Protein S100-B,S100B,
Molecular Weight 10713 DA
Gene ID 6285
NCBI Accession NP_006263
UniProt P04271
Research Area Cell Structure
Application Notes WB = 1:100-250
Restrictions For Research Use only
Format Liquid
Concentration 1.4 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment S100B Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-S100 Calcium Binding Protein B (S100B) antibody S100B Antibody western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the S100B antibody detected the S100B protein (arrow).
Background publications Lin, Yang, Wilder et al.: "The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant melanoma." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 27487-98, 2010 (PubMed).

van Dieck, Lum, Teufel et al.: "S100 proteins interact with the N-terminal domain of MDM2." in: FEBS letters, Vol. 584, Issue 15, pp. 3269-74, 2010 (PubMed).

Egberts, Momkvist, Egberts et al.: "Serum S100B and LDH are not useful in predicting the sentinel node status in melanoma patients." in: Anticancer research, Vol. 30, Issue 5, pp. 1799-805, 2010 (PubMed).

Sahoo, Tröger, Heinemann et al.: "Current inhibition of human EAG1 potassium channels by the Ca2+ binding protein S100B." in: FEBS letters, Vol. 584, Issue 18, pp. 3896-900, 2010 (PubMed).

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