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+1 404 474 4654 |
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+1 888 205 9894 (TF) |
CD34 (CD34) antibody
| Antigen | CD34 (CD34) |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human, Rat (Rattus), Mouse (Murine), Cow (Bovine), Pig (Porcine), Dog (Canine), Rabbit |
| Application |
Alternatives Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Immunofluorescence (IF)
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| Catalog no. | ABIN671361 |
| Quantity | 100 µg (1mg/1ml) (Variants) |
| Price | 255.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 5 to 7 Business Days |
Additional Information
| Alternative name | CD34 |
| Immunogen | Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human CD34 |
| Format | Lyophilized |
| Reconstitution | Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%) |
| Isotype | IgG (Matching secondary antibodies) |
| Description | Synonym: CD34 antigen, CD34 molecule, Cluster designation 34, Hematopoietic progenitor cell antigen CD34, HPCA1. |
| Molecular Weight | 36kDa |
| Comments |
Hematopoietic Stem Cell Marker Endothelial Markers Tumor biomarkers The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors as well as on endothelial cells brain and testis. Staining for CD34 has been used to measure angiogenesis which reportedly predicts tumor recurrence. |
Application Details
| Application Notes | WB (1:100-500), ELISA (1:500-1000), IP (1:20-100), IHC-P (1:100-500), IHC-F (1:100-500), Flow-Cyt (1:20-100), IF (1:50-200) |
| Concentration | 1mg/1ml |
| Purification | affinity purified by Protein A |
| Buffer | 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| Storage | Ship at room temperature. Store at -20°C |
| Research Area | Hematopoietic Progenitors, Hematopoietic Stem Cells, Cardiogenesis, Lineage Markers, CD Antigens, Surface Receptors of Immune Cells |
| Restrictions | For Research Use only |
