GNAI3 antibody (AA 241-354)

Catalog No. ABIN686422

This Rabbit Polyclonal antibody specifically detects GNAI3 in ELISA, IF (cc), IF (p), IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for GNAI3 antibody (AA 241-354) (ABIN686422)

Target: GNAI3 (Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 3 (GNAI3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNAI3 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-GNAI3 Antibody

Binding Specificity: AA 241-354

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GNAI3

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for GNAI3

Target: GNAI3 (Guanine Nucleotide Binding Protein (G Protein), alpha Inhibiting Activity Polypeptide 3 (GNAI3))

Alternative Name: GNAI3

Background:

Synonyms: GAI3, 87U6, FLJ26559, G protein alpha inhibiting 3, Gi alpha 3, Gi alpha-3, GNAI3, GNAI3_HUMAN, Guanine nucleotide binding protein G protein alpha inhibiting activity polypeptide 3, Guanine nucleotide binding protein Gk alpha subunit, Guanine nucleotide-binding protein Gk subunit alpha, OTTHUMP00000013368, Gnai3, Guanine nucleotide binding protein G protein, alpha inhibiting 3, G Alpha i-3.

Background: GAI3 is the a subunit of inhibitory trimeric G protein (Gi), which inhibits adenylate cyclase once its G protein coupled receptors (GPCR) such as a2 adrenergic receptors are activated. GAI3 can be inactivated by pertussis toxin. Guanine nucleotide binding proteins are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor regulated K(+) channels.

Gene ID: 2773

Pathways: cAMP Metabolic Process, G-protein mediated Events