SCNN1G antibody (PE-Cy7)

Catalog No. ABIN706089

The PE-Cy7-conjugated Rabbit Polyclonal anti-SCNN1G antibody (ABIN706089) specifically detects SCNN1G in IF (p). The antibody is reactive with Human, Rat, Mouse and Dog samples.

Quick Overview for SCNN1G antibody (PE-Cy7) (ABIN706089)

Target: SCNN1G (Sodium Channel, Nonvoltage-Gated 1, gamma (SCNN1G))

Reactivity: Human, Rat, Mouse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCNN1G antibody is conjugated to PE-Cy7

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-SCNN1G Antibody (PE-Cy7)

Specificity: Excitation / Emission Wavelengths: 480,565,743nm/767nm

Cross-Reactivity: Rat (Rattus), Dog (Canine)

Purification: purified by Protein A

Immunogen: KLH conjugated synthetic peptide derived from human ENaCg

Isotype: IgG

Application Details

Comment:

Excitation / Emission wavelength: 496,565nm / 774nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 µg/µL

Buffer: Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % Gentamicin.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4 °C for 12 months

Expiry Date: 12 months

Target Details for SCNN1G

Target: SCNN1G (Sodium Channel, Nonvoltage-Gated 1, gamma (SCNN1G))

Alternative Name: epithelial Sodium Channel gamma

Background: Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddelﾒs syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).

Molecular Weight: 60-75kDa

Gene ID: 6340