DCUN1D1 antibody (AA 101-200) (Cy5.5)

Catalog No. ABIN717556

This Rabbit Polyclonal antibody specifically detects DCUN1D1 in WB, IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for DCUN1D1 antibody (AA 101-200) (Cy5.5) (ABIN717556)

Target: DCUN1D1 (Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCUN1D1 antibody is conjugated to Cy5.5

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-DCUN1D1 Antibody (Cy5.5)

Binding Specificity: AA 101-200

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SCRO/DCUN1D1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DCUN1D1

Target: DCUN1D1 (Defective in Cullin Neddylation 1, Domain Containing 1 (DCUN1D1))

Alternative Name: SCRO

Background:

Synonyms: DCN1 defective in cullin neddylation 1 domain containing 1, DCN1 like protein 1, DCUN1 domain containing protein 1, DCUN1L1, Defective in cullin neddylation protein 1 like protein 1, RP 42, RP42, RP42 homolog, SCCRO, SCRO, Squamous cell carcinoma related oncogene, Tes 3, Tes3.

Background: DCUN1D1 (DCUN1 domain-containing protein 1) contains a DUF298 domain and a UBA-like ubiquitin. Forms part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression. Defects in DCUN1D1 may be a cause of squamous cell carcinomas.Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.

Gene ID: 54165