AP2B1 antibody (AA 351-450)

Catalog No. ABIN731138

The Rabbit Polyclonal anti-AP2B1 antibody is suitable to detect AP2B1 in samples from Human. It has been validated for ELISA, IF (cc), IF (p), IHC (p) and IHC (fro).

Quick Overview for AP2B1 antibody (AA 351-450) (ABIN731138)

Target: AP2B1 (Adaptor-Related Protein Complex 2, beta 1 Subunit (AP2B1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AP2B1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-AP2B1 Antibody

Binding Specificity: AA 351-450

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human beta Adaptin

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for AP2B1

Target: AP2B1 (Adaptor-Related Protein Complex 2, beta 1 Subunit (AP2B1))

Alternative Name: beta Adaptin/AP2 beta

Background:

Synonyms: Adaptin beta 1 beta prime, _-Adaptin, Adaptin _1, Adaptin-_1, Adaptin beta 2 beta, Adaptin beta 2, Adaptin, beta 2 beta, Adaptor protein complex AP 1 beta 1 subunit, Adaptor related protein complex 1 beta 1 subunit, Adaptor related protein complex 1, beta 1 subunit, Adaptor related protein complex 2 beta 1 subunit, Adaptor related protein complex 2, beta 1 subunit, ADTB 1, ADTB 2, ADTB1, ADTB2, AP 1 complex subunit beta 1, AP 105A, AP 105B, AP 2 complex subunit beta 1, AP1 Beta, AP1 complex subunit beta 1, AP105A, AP105B, AP1B1, AP2 beta, AP2 complex subunit beta 1, AP2B1, AP2beta, BAM 22, BAM22, Beta adaptin, Beta prime adaptin, Beta1 adaptin, Beta2 adaptin, CLAPB 1, CLAPB 2, CLAPB1, CLAPB2, Clathrin assembly protein complex 1, Clathrin assembly protein complex 1 beta large chain, Clathrin assembly protein complex 2 beta large chain, Clathrin associated/assembly/adaptor protein large beta 1, Clathrin associated/assembly/adaptor protein large beta 2, DKFZp781K0743, Golgi adaptor HA1/AP1 adaptin beta subunit, Plasma membrane adaptor HA2/AP2 adaptin beta subunit, Plasma membrane adaptor HA2/AP2 adaptor beta subunit, Plasma membrane adaptor HA2/AP2.

Background: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP2 beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.

Gene ID: 2971

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation