Sel-1 Suppressor of Lin-12-Like (C. Elegans) (SEL1L) antibody

Antigen: Sel-1 Suppressor of Lin-12-Like (C. Elegans) (SEL1L)

Synonyms: IBD2, SEL1L1, PRO1063, SEL1-LIKE, Sel1h, AW493766, KIAA4137, mKIAA4137, SEL1L, MGC99195

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus), Pig (Porcine), Cow (Bovine), Rabbit

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Immunofluorescence (IF)

Catalog no.: ABIN735953

Additional Information

Alternative name: SEL1L

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human SEL1L

Format: Lyophilized

Reconstitution: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotype: IgG  (Matching secondary antibodies)

Description: Synonym: Suppressor of lin-12-like Protein, IBD2, PRO1063, Sel 1 like protein, Sel 1 suppressor of lin 12 like, SEL1 LIKE, SEL1LIKE, TSA305, AW493766, KIAA4137, mKIAA4137, Sel1h, Sel1l.

Molecular Weight: 88kDa

Comments:

SEL1L

highly similar to the C elegans sel-1 gene

is a recently cloned human gene whose function is under investigation. SEL1L is differentially expressed in tumors and normal tissues and seems to play a role in tumor growth and aggressiveness. It may be an important negative regulator of the "notch" pathway which acts as a key regulator of the cellular proliferation and specification processes in both vertebrates and invertebrates. SEL1L may function in the protein degradation processes through the ubiquitin-proteosome system and perhaps in regulating important pathways such TGF-beta.It is ubiquitously expressed only in fetal and neoplastic tissues. In normal adult tissues is highly expressed in the acini and in the alpha cells of the pancreas

in general it is highly represented in secretory cells such as plasma cells.

Application Details

Application Notes: WB (1:100-500), ELISA (1:500-1000), IP (1:20-100), IHC-P (1:100-500), IHC-F (1:100-500), Flow-Cyt (1:20-100), IF (1:50-200)

Concentration: 1mg/1ml

Purification: affinity purified by Protein A

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Storage: Ship at room temperature. Store at -20°C

Research Area: Cancer

Restrictions: For Research Use only