Activin A Receptor Type IB/ALK-4 antibody (PE)

Catalog No. ABIN761241

The PE-conjugated Rabbit Polyclonal anti-Activin A Receptor Type IB/ALK-4 antibody (ABIN761241) specifically detects Activin A Receptor Type IB/ALK-4 in IF (p). The antibody is reactive with Human, Mouse, Rat, Cow, Dog and Pig samples.

Quick Overview for Activin A Receptor Type IB/ALK-4 antibody (PE) (ABIN761241)

Target: Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Activin A Receptor Type IB/ALK-4 antibody is conjugated to PE

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Activin A Receptor Type IB/ALK-4 Antibody (PE)

Specificity: Excitation / Emission Wavelengths: 565nm/578nm

Cross-Reactivity: Rat (Rattus), Dog (Canine), Pig (Porcine), Cow (Bovine)

Purification: purified by Protein A

Immunogen: KLH conjugated synthetic peptide derived from human ACVR1B

Isotype: IgG

Application Details

Comment:

Excitation / Emission wavelength: 496nm / 578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 µg/µL

Buffer: Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4 °C for 12 months

Expiry Date: 12 months

Target Details for Activin A Receptor Type IB/ALK-4

Target: Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))

Alternative Name: ACVR1B

Background: [FUNCTION]Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.

Molecular Weight: 57kDa

Gene ID: 91