SAA antibody

Catalog No. ABIN782005

This Mouse Monoclonal antibody specifically detects SAA in WB, EIA, ELISA (Detection) and ELISA (Capture). It exhibits reactivity toward Human.

Quick Overview for SAA antibody (ABIN782005)

Target: SAA (Serum Amyloid A (SAA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SAA antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), ELISA (Detection), ELISA (Capture)

Clone: B336A

Product Details anti-SAA Antibody

Specificity: This antibody recognizes native and recombinant Serum Amyloid A (SAA).

Purification: Affinity Chromatography on Protein A

Immunogen: Human recombinant SAA, conjugated with carrier protein

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 2.9 mg/mL

Buffer: PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for SAA

Target: SAA (Serum Amyloid A (SAA))

Alternative Name: Serum Amyloid A Protein (SAA)

Background: The Serum Amyloid A (SAA) family comprises a number of differentially expressed lipoproteins, acute phase SAA1 and SAA2, the former being a major component in plasma, and constitutive SAA's (C-SAAs). Although the liver is the primary site of synthesis of both SAA types, extrhepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed it's importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations. SAA rises earlier and more sharply than CRP. SAA enhances the binding of HDL's to macrophages and thus helps the delivery of lipid to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease process. In addition, recent experiments suggest that SAA may play a "houekeeping" role in normal human tissues. Elevated levels of SAA over time predispose secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid artheritis.Synonyms: SAA1, SAA2

Gene ID: 6288

NCBI Accession: NP_000322

UniProt: P02735