This antibody detects VPS39 / VAM6 at C-term. At least four isoforms of VPS39 are known to exist, this antibody will detect all four. VPS39 antibody is predicted not to cross-react with TRAP1.
Cross-Reactivity (Details)
Species reactivity (tested):Human, mouse, rat
Purification
Affinity chromatography purified via peptide column
Immunogen
18 amino acid peptide near the carboxy terminus of human VPS39
VPS39
Reactivity: Human
ELISA
Host: Rabbit
Polyclonal
FITC
Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Buffer
PBS containing 0.02 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Target
VPS39
(Vacuolar Protein Sorting 39 Homolog (VPS39))
Alternative Name
VPS39
Background
VPS39 is the mammalian homolog of the yeast vacuolar protein VAM6, that in mammals, promotes lysosome clustering and fusion in vivo. VPS39 is also thought to modulate the TGF-b response by coupling the TGF-b receptor complex to the Smad pathway. Similar to the related protein TRAP1, the VPS39 protein is essential for early embryonic development, with mice lacking VPS39 dying at or before E6.5.Synonyms: KIAA0770, VAM6, Vam6/Vps39-like protein