ZNF281 antibody (C-Term)

Catalog No. ABIN783429

Product Details anti-ZNF281 Antibody

Target: ZNF281 (Zinc Finger Protein 281 (ZNF281))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNF281 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects ZNF281 at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the carboxy terminus of human ZFP281

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for ZNF281

Target: ZNF281 (Zinc Finger Protein 281 (ZNF281))

Alternative Name: ZNF281 (ZNF281 Products)

Background: ZFP281, also known as ZBP-99, is a member of a conserved family of transcription factors that interact with GC-rich promoters. It contains four Kruppel-like zinc fingers and is highly homologous to ZBP-89, another regulator of ornithine decarboxylase gene expression. ZFP281 also interacts with many other other transcription factors, such as Sp1 to repress vimentin gene transcription. ZFP281 has also been shown to control embryonic stem cell pluripotency by direct regulating specific target genes. ZFP281 phyically interacts with the transcription factos POU5F1, Sox2, and NANOG. Gene expression microarray anlysis indicated that some ZFP281 target genes were activated, while others were repressed upon knockdown of ZFP281 expression, showing that ZFP281 plays bifuctinal roles in regulating gene expression in stem cells.Synonyms: GC-box-binding zinc finger protein 1, GZP1, ZBP-99, ZBP99, Zinc finger DNA-binding protein 99, Zinc finger protein 281

Gene ID: 23528

NCBI Accession: NP_036614

UniProt: Q9Y2X9

Pathways: Embryonic Body Morphogenesis