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Tectonic Family Member 1 (TCTN1) (N-Term) antibody

Details for Product No. ABIN783637
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Antigen
Synonyms FLJ21127, JBTS13, TECT1, G730031O11Rik, Tect1, RGD1566266
Epitope
N-Term
(12), (7)
Reactivity
Human, Mouse (Murine)
(25), (22), (18), (12), (12)
Host
Rabbit
(26), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(18), (10), (10), (8), (3), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN783637
401.50 $
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Immunogen 15 amino acid peptide near the amino terminus of human TCTN1
Specificity This antibody detects TCTN1 . It is predicted to not cross-react with other TCTN members. Multiple isoforms are known to exist, this antibody recognizes isoforms 1 – 3. Species Reactivity: Tested: Human, Mouse
Purification Affinity chromatography purified via peptide column
Alternative Name Tectonic-1
Background TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
Alternate names: TCTN1, TECT1
Gene ID 79600
NCBI Accession NP_001076006
UniProt Q2MV58
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Reiter, Skarnes: "Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition." in: Genes & development, Vol. 20, Issue 1, pp. 22-7, 2006 (PubMed).

Validation Images
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