SYNPO2 antibody (N-Term)

Catalog No. ABIN783775

Product Details anti-SYNPO2 Antibody

Target: SYNPO2 (Synaptopodin 2 (SYNPO2))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYNPO2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects SYNPO2 at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogen: 20 amino acid peptide near the amino terminus of human SYNPO2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Target Details for SYNPO2

Target: SYNPO2 (Synaptopodin 2 (SYNPO2))

Alternative Name: SYNPO2 (SYNPO2 Products)

Synonyms: SYNOP2 antibody, RGD1564779 antibody, 1110069I04Rik antibody, 2310068J10Rik antibody, 9530006G20Rik antibody, AI848603 antibody, Myo antibody, synaptopodin 2 antibody, synaptopodin-2 antibody, SYNPO2 antibody, LOC100484043 antibody, Synpo2 antibody

Background: SYNPO2 was initially identified as myopodin, a member of the synaptopodin family that contains one PPXY motif and multiple PXXP motifs. It colocalizes with alpha-actinin and is found at the Z-disc and during stress conditions will translocate to the nucleus, suggesting that it is part of signaling pathways in addition to its function as a structural protein. SYNPO2 has been shown to bind to calmodulin, alpha-actinin, and smooth muscle myosin and will stimulate actin polymerization in a calmodulin dependent manner, consistent with its proposed role in organizing the cytoskeleton. While deletion of SYNPO2 has been reported to be highly correlated with the invasiveness of prostate cancers, other reports suggest that down-regulation of SYNPO2 reduces the invasiveness and motility of prostate cancer cells.

Gene ID: 171024

NCBI Accession: NP_001122405

UniProt: Q9UMS6