PCSK6 antibody (Internal Region)

Catalog No. ABIN783982

This Goat Polyclonal antibody specifically detects PCSK6 in IHC (p) and EIA. It exhibits reactivity toward Human.

Quick Overview for PCSK6 antibody (Internal Region) (ABIN783982)

Target: PCSK6 (Proprotein Convertase Subtilisin/kexin Type 6 (PCSK6))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This PCSK6 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-PCSK6 Antibody

Binding Specificity: Internal Region

Sequence: C-YHTFSAHQSR SR

Specificity: Recognizes PCSK6 / PACE4. This antibody is expected to recognize reported isoforms a (NP_002561.1), b (NP_612192.1), g (NP_612193.1) and h (NP_612194.1).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_002561.1, NP_612192.1, NP_612195.1, NP_612197.1, NP_612196.1, NP_612198.2, NP_612193.1, NP_612194.1. Genename: PCSK6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PCSK6

Target: PCSK6 (Proprotein Convertase Subtilisin/kexin Type 6 (PCSK6))

Alternative Name: PCSK6 / PACE4

Background: PACE4 belongs to the peptidase S8 family. Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif. Each PACE4 isoform exhibits a unique restricted distribution. Isoform PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. Isoform PACE4A-II is at least expressed in placenta. Isoform PACE4B was only found in the embryonic kidney cell line from which it was isolated. Isoform PACE4C and isoform PACE4D are expressed in placenta. Isoform PACE4E-I is expressed in cerebellum, placenta and pituitary. Isoform PACE4E-II is at least present in cerebellum.Synonyms: Paired basic amino acid cleaving enzyme 4, Proprotein convertase subtilisin/kexin type 6, SPC4, Subtilisin-like proprotein convertase 4, Subtilisin/kexin-like protease PACE4

Gene ID: 5046

NCBI Accession: NP_002561

Pathways: Neurotrophin Signaling Pathway, SARS-CoV-2 Protein Interactome