USP6 antibody (C-Term)

Catalog No. ABIN784289

The Goat Polyclonal anti-USP6 antibody is suitable to detect USP6 in samples from Human. It has been validated for WB and EIA.

Quick Overview for USP6 antibody (C-Term) (ABIN784289)

Target: USP6 (Ubiquitin Specific Peptidase 6 (USP6))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This USP6 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-USP6 Antibody

Binding Specificity: C-Term

Sequence: KISPLHHLQM ECSP

Specificity: This antibody recognizes USP6/TRE2/TRE17

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the C Terminus of the protein sequence according to NP_004496.1. Genename: USP6

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for USP6

Target: USP6 (Ubiquitin Specific Peptidase 6 (USP6))

Alternative Name: USP6 / TRE2

Background: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16,17)(q22,p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation.Synonyms: Deubiquitinating enzyme 6, HRP1, TRE-2, Ubiquitin carboxyl-terminal hydrolase 6, Ubiquitin thioesterase 6, Ubiquitin-specific-processing protease 6

Gene ID: 9098

NCBI Accession: NP_004496