DARC antibody (N-Term)

Catalog No. ABIN784594

This Rabbit Polyclonal antibody specifically detects DARC in IF, IHC (p) and EIA. It exhibits reactivity toward Human.

Quick Overview for DARC antibody (N-Term) (ABIN784594)

Target: DARC (Duffy Blood Group, Chemokine Receptor (DARC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DARC antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-DARC Antibody

Binding Specificity: N-Term

Specificity: This antibody detects endogenous levels of total CD234 protein.

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide from human DARC. Remarks: Antigen Modification: N-Terminus

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM Sodium Chloride, 0.02 % Sodium Azide and 50 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C or lower. Avoid freeze-thaw cycles.

Target Details for DARC

Target: DARC (Duffy Blood Group, Chemokine Receptor (DARC))

Alternative Name: CD234 / DARC

Background: Duffy blood group antigens, part of the Chemokine Receptor family, appear to be multimeric erythrocyte-membrane protein receptors composed of different subunits. A glycoprotein, GPD, is the major subunit of the protein complex. Other components include the Rh, PGM1, Fy, and PEPC proteins. Duffy antigen is expressed by red blood cells, by postcapillary venule endothelium throughout the body, except in the liver, and by Purkinje cells of the cerebellum. Duffy negativity (lack of Duffy expression in bone marrow) has been linked to protection against malaria. In erythrocytes, the chemokines interleukin-8 and melanoma growth stimulatory activity (MGSA) activate Duffy antigen.Synonyms: Duffy antigen/chemokine receptor, FY, Fy glycoprotein, GPD, Glycoprotein D, GpFy, Plasmodium vivax receptor

Gene ID: 2532

NCBI Accession: NP_001116423