Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1) (C-Term) antibody

Details for Product No. ABIN785711
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Antigen
Synonyms DT1P1B11, PHRIP, TDAG51, Tdag
Epitope
C-Term
(7), (6), (4), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Xenopus laevis, Cow (Bovine), Human
(39), (22), (20), (13), (12)
Host
Rabbit
(37), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(30), (13), (10), (3), (2), (2)
Pubmed 2 references available
Quantity 50 μg
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Catalog No. ABIN785711
289.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human PHLDA1
Sequence LAVKSTRQKQ QHLVQQQPPS QPQPQPQLQP QPQPQPQPQP QPQSQPQPQP
Predicted Reactivity African clawed frog : 100 %, Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Rabbit : 100 %, Rat : 100 %
Characteristics This is a rabbit polyclonal antibody against PHLDA1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name PHLDA1
Background PHLDA1 is an evolutionarily conserved proline-histidine rich nuclear protein. It may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.
Molecular Weight 45 kDa
Gene ID 22822
NCBI Accession NM_007350, NP_031376
UniProt Q8WV24
Research Area Apoptosis/Necrosis
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 401 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1) (C-Term) antibody WB Suggested Anti-PHLDA1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human Placenta
Product cited in: Tsuda, Davis, Argani et al.: "TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition." in: Cancer research, Vol. 67, Issue 3, pp. 919-29, 2007 (PubMed).

Background publications Nagai, Fregnani, Netto et al.: "Down-regulation of PHLDA1 gene expression is associated with breast cancer progression." in: Breast cancer research and treatment, Vol. 106, Issue 1, pp. 49-56, 2007 (PubMed).

Validation Images
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