Integrin beta 3 (ITGB3) antibody

Details for Product No. ABIN810075
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Antigen
Synonyms CD61, GP3A, INGRB3, BDPLT16, BDPLT2, GPIIIa, GT, INTB3, integrin, GPIIIA
Reactivity
Human, Non-Human Primate
(312), (174), (85), (48), (43), (25), (24), (9), (3), (2), (1), (1), (1)
Host
Mouse
(171), (160), (60), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(56), (38), (24), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Western Blotting (WB)
(204), (174), (67), (67), (52), (51), (37), (30), (13), (12), (10), (8), (3), (1)
Pubmed 6 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN810075
290.40 $
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Clone VIPL2
Isotype IgG1
Specificity The mouse monoclonal antibody VIPL2 recognizes CD61, a 90-110 kDa transmembrane glycoprotein of integrin family, expressed on platelets, megacaryocytes, osteoclasts, endothelial cells and other cell types, including leucocytes and smooth muscle cells.HLDA V., WS Code 5T-124
Purification Purified from cell culture supernatant by protein-A affinity chromatography.
Purity > 95 % (by SDS-PAGE)
Alternative Name ITGB3
Background CD61 (beta3 integrin) is a transmembrane glycoprotein, which associates with CD41 or CD51 molecules to form heterodimeric adhesion receptores. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. It binds to fibronectin, fibrinogen and von Willebrand factor, and is involved in platelet aggregation. CD51/CD61 complex has similar binding properties and is involved in modulating migration and survival of angiogenic endothelial cells.
Gene ID 3690
Application Notes Working concentrations should be determined by the investigator.I t is recommended that the user titrates the reagent for use in the particular testing system.

Working concentrations should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8 °C. Do not use after expiration date stamped on vial label.
Product cited in: Dzionek, Fuchs, Schmidt et al.: "BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 11, pp. 6037-46, 2000 (PubMed).

Ciarlet, Crawford, Cheng et al.: "VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment." in: Journal of virology, Vol. 76, Issue 3, pp. 1109-23, 2002 (PubMed).

Roberts, Woods, Dale et al.: "Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins." in: Molecular and cellular biology, Vol. 24, Issue 4, pp. 1505-15, 2004 (PubMed).

Mondal, Williams, Ali et al.: "The HIV-1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells." in: Experimental biology and medicine (Maywood, N.J.), Vol. 230, Issue 9, pp. 631-44, 2005 (PubMed).

Williams, Mondal, Agrawal: "The HIV-1 Tat protein enhances megakaryocytic commitment of K562 cells by facilitating CREB transcription factor coactivation by CBP." in: Experimental biology and medicine (Maywood, N.J.), Vol. 230, Issue 11, pp. 872-84, 2005 (PubMed).

Barrett, Dai, Gamberg et al.: "Circulating CD14-CD36+ peripheral blood mononuclear cells constitutively produce interleukin-10." in: Journal of leukocyte biology, Vol. 82, Issue 1, pp. 152-60, 2007 (PubMed).

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