CYP2A6 antibody

Catalog No. ABIN2718978

Cited in 1 publication. The Mouse Monoclonal anti-CYP2A6 antibody (Clone 2A8) (ABIN2718978) specifically detects CYP2A6 in WB, IF, IHC and FACS. The antibody is reactive with Human samples.

Quick Overview for CYP2A6 antibody (ABIN2718978)

Target: CYP2A6 (Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CYP2A6 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 2A8

Product Details anti-CYP2A6 Antibody

Characteristics: Homo sapiens cytochrome P450, family 2, subfamily A, polypeptide 6 (CYP2A6)

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human CYP2A6(NP_000753) produced in HEK293T cell.

Isotype: IgG2b

Application Details

Application Notes: WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-CYP2A6 antibody (ABIN2718978)

Huang, Guo, Li, Zhang: "Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes." in: Scientific reports, Vol. 7, pp. 40716, (2018) (PubMed).

Target Details for CYP2A6

Target: CYP2A6 (Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6))

Alternative Name: CYP2A6

Background: This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3, however, it has been renamed CYP2A6.

Molecular Weight: 56.3 kDa

Gene ID: 1548

NCBI Accession: NM_000762

HGNC: 1548