SNAIL antibody

Catalog No. ABIN865486

This Mouse Monoclonal antibody specifically detects SNAIL in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for SNAIL antibody (ABIN865486)

Target: SNAIL (SNAI1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SNAIL antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 6D2

Product Details anti-SNAIL Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human SNAI1 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100g/100l

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for SNAIL

Target: SNAIL (SNAI1)

Alternative Name: SNAI1

Background: Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function . Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney. Synonyms: SNA, SNAH, SLUGH2, dJ710H13.1, SNAI1

Molecular Weight: 29kDa

Gene ID: 6615

Pathways: Negative Regulation of intrinsic apoptotic Signaling