KDM3A antibody

Catalog No. ABIN865496

The Mouse Monoclonal anti-KDM3A antibody is suitable to detect KDM3A in samples from Human. It has been validated for WB, ELISA and IF.

Quick Overview for KDM3A antibody (ABIN865496)

Target: KDM3A (Lysine (K)-Specific Demethylase 3A (KDM3A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KDM3A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: 2E1

Product Details anti-KDM3A Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human KDM3A expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: WB: 1/500 - 1/2000, IF: 1/200 - 1/1000, ELISA: Propose dilution 1/10000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100g/100l

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for KDM3A

Target: KDM3A (Lysine (K)-Specific Demethylase 3A (KDM3A))

Alternative Name: KDM3A

Background: This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and -ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis. Synonyms: TSGA, JMJD1, JHDM2A, JHMD2A, JMJD1A, KIAA0742, DKFZp686A24246, DKFZp686P07111, KDM3A

Molecular Weight: 147kDa

Gene ID: 55818

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Warburg Effect