Small Basement Membrane Heparan Sulfate Proteoglycan antibody
The Mouse Monoclonal anti-Small Basement Membrane Heparan Sulfate Proteoglycan antibody is suitable to detect Small Basement Membrane Heparan Sulfate Proteoglycan in samples from Human. It has been validated for WB, IHC and ELISA.
Catalog No. ABIN870824
$137.28
Plus shipping costs $50.00
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Quick Overview for Small Basement Membrane Heparan Sulfate Proteoglycan antibody (ABIN870824)
Target
Small Basement Membrane Heparan Sulfate Proteoglycan
Reactivity
Human
Host
Mouse
Clonality
Monoclonal
Conjugate
Un-conjugated
Application
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
Clone
1F10-B8
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Specificity
- Monoclonal Ab 1F10/B8 is specific for a core protein epitope of a human small basement membrane heparan sulfate proteoglycan (HS-PG). MAb 1F10/B8 recognizes an epitope different from that recognized by mAb 2H7/G11 and mAb 2E2/B5. Whereas previously perlecan was the only known basement membrane HS-PG, there is now evidence that at least two other basement membrane HS-PG exist: Agrin, originally discovered as an important component of the neuromuscular junction, and a novel small HS-PG which was isolated from human aorta and kidney. This HS-PG, with a molecular weight of 80-200 kDa (aorta) and 30-160 kDa (kidney) and a core protein size of 24 kDa or 22 kDa, respectively, was localized by immunohistochemistry to the basement membrane. Amino acid sequence analysis of tryptic peptides indicate, that this small HS-PG is clearly distinct from perlecan and agrin.
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Purification
- Purified human small basement membrane heparan sulfate proteoglycan (HS-PG). Protein G purified.
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Isotype
- IgG1 kappa
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Application Notes
- ELISA (less than 1µg/ml), Western Blot (1µg/ml), immunohistochemistry (1µg/ml). This antibody has not been tested for use in all applications. This does not necessarily exclude its use for non-tested procedures. The stated dilutions are recommendations only.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Resuspend in aqua bidest.
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Buffer
- 50 mM TRIS pH 7.4
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Storage
- 4 °C
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- Small Basement Membrane Heparan Sulfate Proteoglycan
Target
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