Microtubule-Associated Protein tau (MAPT) (pSer416) antibody

Details for Product No. ABIN871413
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms tau, xtp, MAPT, AI426939, AI551861, AW457082, CK1epsilon, CKIe, KC1epsilon, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU, AI413597, AW045860, Mtapt, Tau, PHF-tau, RNPTAU, pTau
Epitope
pSer416
(42), (37), (35), (34), (32), (32), (30), (30), (29), (29), (29), (26), (26), (24), (17), (14), (13), (12), (12), (12), (11), (11), (11), (10), (10), (10), (9), (9), (9), (9), (8), (8), (8), (7), (6), (6), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus)
(929), (471), (450), (63), (15), (8), (6), (3), (2), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(876), (93), (9), (9), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (6), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(858), (337), (255), (96), (88), (47), (38), (38), (25), (20), (16), (10), (7), (2)
Pubmed 3 references available
Quantity 100 μL
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN871413
286.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Peptide sequence around phosphorylation site of pSer416 (T-G-S (p) -I-D) derived from Rat Tau. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Specificity The antibody detects endogenous levels of Tau only when phosphorylated at serine 416.
Purification Affinity purified
Alternative Name Tau
Background Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies
Molecular Weight 78 kDa
Gene ID 29477
NCBI Accession NP_058908
UniProt P19332
Research Area Neurology, Cytoskeleton, Alzheimer's Disease
Application Notes Western blotting: 1:500-1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Bramblett, Goedert, Jakes et al.: "Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding." in: Neuron, Vol. 10, Issue 6, pp. 1089-99, 1993 (PubMed).

Hanger, Betts, Loviny et al.: "New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry." in: Journal of neurochemistry, Vol. 71, Issue 6, pp. 2465-76, 1998 (PubMed).

Watt, Sever: "Non-profit publishing: open access and the end of copyright transfer." in: Journal of cell science, Vol. 117, Issue Pt 1, pp. 1, 2003 (PubMed).

Validation Images
Did you look for something else?
back to top