MAPKAP Kinase 3 antibody (C-Term)

Catalog No. ABIN926459

The Rabbit Polyclonal anti-MAPKAP Kinase 3 antibody is suitable to detect MAPKAP Kinase 3 in samples from Human. It has been validated for WB.

Quick Overview for MAPKAP Kinase 3 antibody (C-Term) (ABIN926459)

Target: MAPKAP Kinase 3 (MAPKAPK3) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPKAP Kinase 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MAPKAP Kinase 3 Antibody

Binding Specificity: C-Term

Purification: Purified

Immunogen: MAPKAPK3 antibody was raised in rabbit using the C terminal of MAPKAPK3 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

MAPKAPK3 Blocking Peptide, (ABIN939713), is also available for use as a blocking control in assays to test for specificity of this MAPKAPK3 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for MAPKAP Kinase 3

Target: MAPKAP Kinase 3 (MAPKAPK3) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))

Alternative Name: MAPKAPK3

Background: MAPKAPK3 is a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Synonyms: Polyclonal MAPKAPK3 antibody, Anti-MAPKAPK3 antibody, mitogen-activated protein kinase-activated protein kinase 3 antibody, 3PK antibody, MAPKAP3 antibody.

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades