Endothelin 3 antibody (C-Term)

Catalog No. ABIN926685

The Rabbit Polyclonal anti-Endothelin 3 antibody (ABIN926685) specifically detects Endothelin 3 in WB. The antibody is reactive with Human samples.

Quick Overview for Endothelin 3 antibody (C-Term) (ABIN926685)

Target: Endothelin 3 (EDN3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Endothelin 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Endothelin 3 Antibody

Binding Specificity: C-Term

Purification: Purified

Immunogen: EDN3 antibody was raised in rabbit using the C terminal of EDN3 as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

EDN3 Blocking Peptide, (ABIN940397), is also available for use as a blocking control in assays to test for specificity of this EDN3 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for Endothelin 3

Target: Endothelin 3 (EDN3)

Alternative Name: EDN3

Background: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed. Synonyms: Polyclonal EDN3 antibody, Anti-EDN3 antibody, endothelin 3 antibody, ET3 antibody, MGC15067 antibody, MGC61498 antibody.

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones