Endothelin 3 antibody

Catalog No. ABIN7257539

The Rabbit Polyclonal anti-Endothelin 3 antibody (ABIN7257539) specifically detects Endothelin 3 in IHC. The antibody is reactive with Mouse samples.

Quick Overview for Endothelin 3 antibody (ABIN7257539)

Target: Endothelin 3 (EDN3)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Endothelin 3 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-Endothelin 3 Antibody

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human EDN3 (NP_996917.1).

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Endothelin 3

Target: Endothelin 3 (EDN3)

Alternative Name: EDN3

Background: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID: 1908

UniProt: P14138

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones